We retrospectively analyzed 3 middle-aged male patients of primary malignant tumor of uvula.There was a long history of smoking and drinking for the patients.All of them came to the hospital with the syptoms of pharyngeal foreign body sensation and two of them had pharyngeal sore.The patients appeared well,new neoplasm at the apex of the uvula.Diameter of 2 cases were less than 1 cm without invading the midline of the soft palate.Another patient's diameter was more than 1 cm with invading the midline of the soft palate.Preoperative pathology diagnosis of 3 patients was squamous cell carcinoma of uvula.The pharyngeal CT of the patient with invading the midline of the soft palate showed nodules at the end of the soft palate,obviously enhancement and small lymph node in left neck.