Fast Electrical Detection of Carcinoembryonic Antigen Based on AlGaN/GaN High Electron Mobility Transistor Aptasensor

• 来源期刊: 中国物理快报（英文版）
• 关键词: @@
• 年，卷（期）: 2017,（9）
• 页码范围: 87-90
• 页数: 4页
• 语种: 英文
• DOI: 10.1088/0256-307X/34/9/097302

摘要

As one of the most important tumor-associated antigens of colorectal adenocarcinoma,the carcinoembryonic antigen (CEA) threatens human health seriously all over the globe.Fast electrical and highly sensitive detection of the CEA with AlGaN/GaN high electron mobility transistor is demonstrated experimentally.To achieve a low detection limit,the Au-gated sensing area of the sensor is functionalized with a CEA aptamer instead of the corresponding antibody.The proposed aptasensor has successfully detected different concentrations (ranging from 50 picogram/milliliter (pg/ml) to 50nanogram/milliliter (ng/ml)) of CEA and achieved a detection limit as low as 50pg/ml at Vds =0.5 V.The drain-source current shows a clear increase of 11.5 μA under this bias.