OSAHS生物标己物的研究进展及意义

• 作者: 周宁 唐旋 杨立新 颜杰
• 来源期刊: 临床耳鼻咽喉头颈外科杂志
• 学科: 医学
• 关键词: 睡眠呼吸暂停低通气综合征,阻塞性 生物标记物 蛋白质组学 代谢组学
• 年，卷（期）: 2017,（19）
• 所属期刊栏目: 综述
• 页码范围: 1540-1544
• 页数: 5页
• 分类号: R563.8
• 语种: 中文
• DOI: 10.13201/j.issn.1001-1781.2017.19.019

摘要

To review the application of proteomics and metabolomics in the study of OSAHS biomarkers,and to open a new perspective for the study of OSAHS.At present,these studies are still in a very preliminary stage,the results are not always consistent,and far from the clinical application requirements.However,compared with traditional chemical methods,quantitative protein and metabolomics methods still have many advantages and have great clinical potential.Further studies of larger populations for more detailed grouping in the future are necessary to validate these results,and a more structured investigation in cell and animal models is necessary to determine their molecular mechanisms.In addition,the combination of different analytical platforms will be the ideal method for OSAHS biomarker research.In conclusion,the proteomics and metabolomics methods help us to better understand the potential mechanisms of OSAHS and to discover and develop personalized screening,diagnosis,prognostic and therapeutic strategies for future research.