Head and neck squamous cell carcinoma,HNSCC,has high morbidity and mortality.Even in America,more than 1/2 to 2/3 patients have been diagnosed at advanced stage.So,it's urgent to find ways to diagnose HNSCC earlier and foresee the curative effect.With the achievement of Next-Generation Sequencing,researchers are trying to develop early diagnostic technology from a new perspective,such as personal genomics,proteomics,metabolomics and other related personal information.Here we reviewed the recent research in early diagnosis of HNSCC.