New insight in a new entity: the mitochondrial permeability transition pore arises from the Ca2+-activated F1FO-ATPases

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2018,（3）
• 页码范围: 143-145
• 页数: 3页
• 语种: 英文

摘要

The mitochondrial permeability transition pore (MPTP) is linked to pathways leading to different variant of cell death and the molecular mechanism of MPTP opening is considered a promising approach from structure to medicine therapy [1].However,the nature of MPTP is enigmatic,because the formation and opening of channel remain an arcane puzzle triggered by F1FO-ATPase in presence of at high Ca2+ concentrations in mitochondria [2].