Targeted molecular therapy (modified RIST regimen) in relapsed high risk stage Ⅳ neuroblastoma: two cases report

• 作者: Antonio Marte Cristiana Indolfi Daniela Di Pinto Elvira Pota Fiorina Casale Francesca Rossi Martina Di Martino Paolo Indolfi Selim Corbacioglu Silverio Perrotta
• 来源期刊: 儿科理论与临床(英文)
• 学科: 医学
• 关键词: RIST THERAPY NEUROBLASTOMA PEDIATRIC cancer
• 年，卷（期）: ekllylcyw_2018,（1）
• 页码范围: 2-4
• 页数: 3页
• 分类号: R

摘要

The prognosis for children with recurrent or refractory neuroblastoma remains a significant clinical challenge,and currently there are no known curative salvage regimens.In this paper we investigated the effect of imatinib with rapamycin and the chemotherapeutic agents temozolomide and irinotecan.We treated two children with recurrent neuroblastoma with this so called RIST protocol.Both patients,off therapy for 15 and 31 months,respectively are well,and developing normally,without any complications.These findings suggest that a combination regimen of RIST may provide a therapeutic benefit with a favorable toxicity profile to a unfortunate subset of patients with neuroblastoma.