Emergent Mitotic Chromosome Motions from a Changing Intracellular pH

• 作者: Daniel H. Shain L. John Gagliardi
• 来源期刊: 生物物理学期刊(英文)
• 学科: 医学
• 关键词: MITOSIS Ndc80/Hec1 ELECTROSTATICS CHROMOSOME MOTILITY COMPLEXITY Theory
• 年，卷（期）: 2018,（1）
• 页码范围: 9-21
• 页数: 13页
• 分类号: R73

摘要

The mechanism by which chromosomes establish and maintain a dynamic coupling to microtubules for force generation during the complex motions of mitosis remains elusive. Equally challenging is an explanation for the timing of poleward, antipoleward, and oscillatory chromosome movements. The molecular cell biology paradigm requires that specific molecules, or molecular geometries, for force generation are necessary for chromosome motions. We propose here that the dynamics of mitotic chromosome motions are an emergent property of a changing intracellular pH in combination with electrostatic forces. We explain this mechanism within the context of Complexity Theory, based on the electrostatic properties of tubulin, known cellular electric charge distributions, and the dynamic instability of microtubules.