Metabolomics:From liver chiromancy to personalized precision medicine in advanced chronic liver disease

• 作者: Bogdan Procopet Horia Stefanescu Oana Farcau Petra Fischer
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Metabolomics BIOMARKER Prediction ADVANCED chronic LIVER disease DECOMPENSATION ALCOHOLIC hepatitis Hepatocellular carcinoma
• 年，卷（期）: 2018,（3）
• 页码范围: 371-378
• 页数: 8页
• 分类号: R

摘要

Currently there is a lack of accurate biomarkers for diagnosis and prognosis in advanced liver diseases.Either the occurrence of first decompensation,or diagnosis of acute on chronic liver failure,severe alcoholic hepatitis,or hepatocellular carcinoma(HCC),none of the available biomarkers are satisfactory.Metabolomics is the newest of omics,being much closer than the others to the actual phenotype and pathologic changes that characterizes a certain condition.It deals with a much wider spectrum of low molecular weight bio-compounds providing a powerful platform for discovering novel biomarkers and biochemical pathways to improve diagnostic,prognostication and therapy.Until now metabolomics was applied in a wide spectrum of liver conditions,but the findings were contradictory.This review proposes a synthesis of the existing evidences of metabolomics use in advanced chronic liver diseases,decompensated liver cirrhosis,severe alcoholic hepatitis and HCC.