Objective: We aim to study the relationship between migraine and obesity at Titirou in Parakou in 2017. Method: It was a case-control study which included 66 migrainers according to International Headache Society (IHS) criteria 2013 (case) matched to 132 controls by age, sex and residence. Size and weight have been measured in each subject. Body mass index has been calculated. Migraine history and sociodemographic information have been collected from 1st May to 31st August 2017 and analyzed by using Epi Info 7 software. The association between migraine and obesity was estimated by odds ratio and their confidence interval. Results: There has been no difference among those suffering from migraine and controls according to sociodemographic characteritics. Obesity has significantly been associated with migraine with OR 4.24 (1.93 - 9.25). The weight more than 70 Kg has been associated with the migraine with OR: 2.02 (1.06 - 3.90). The overweight and obesity have been associated with migraine OR with respectively 1.9 (1.1 - 3.9) and 4.4 (2.0 - 9.5). No difference has been found between migraine and the clinical characteristics of migraine (type, severity, intensity). Conclusion: Obesity has been associated with migraine and has to be taken into account in migraine management.