Polysaccharide from Fruits of Physalis Alkekengi L. Enhances Antitumor Efficacy by a DNA Vaccine

• 作者: Donglin Zhu Gang Xiao Hua Li Jing Huang Jingping Liu Yun Xi
• 来源期刊: 医学科学进展杂志(英文)
• 学科: 医学
• 关键词: ADJUVANT DNA VACCINE PHYSALIS alkekengi L. Polysaccharidel
• 年，卷（期）: 2018,（4）
• 页码范围: 115-120
• 页数: 6页
• 分类号: R

摘要

Physalis. alkekengi fruit has long been used in traditional Chinese medicine for tumor therapy. In the present study, using plasmids that encode ovalbumin (OVA) gene, we investigate the adjuvant activity of a polysaccharide fraction (PPSB) isolated from P.alkekengi fruit. Formulation by simple procedures of mixing of the OVA-encoding pCI-neo-sOVA plasmid with PPSB not only induced specific antibody responses, but also induced antigen-specific cytotoxic T lymphocyte (CTL) responses (Graph abstract). Furthermore, immunization using this vaccine prevented the growth of OVA-expressing B16-OVA tumor cell growth in the immunized mice. Thus, we provide evidence supporting the adjuvant activity of PPSB in DNA vaccine against tumor.