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摘要:
The new generations of nano-devices successfully apply with great promise as drug carriers in the treatment of different diseases. The proposed model aims to determine the pharmacological targets and evaluate the bio-safety of usefulness of carbon nanotube conjugated with two different antiviral compounds, Acetylcholine and Ravastigmine, for treating Alzheimer disease. We also obtain the medicinal model mathematically to evaluate the interaction energy arising from encapsulation of each antiviral compound inside the single-walled carbon nanotube. Acetylcholine is modelled as two-connected spheres, while Ravastigmine has two possible structures which are an ellipsoid and cylinder, all interacting with the interior wall of single-walled carbon nanotubes with variant radii rc . Our calculations show that the single-walled carbon nanotube of radius rc greater than 3.391 Åthat will accept both drugs which are quite closer to the recent findings.
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篇名 Modelling of the Usefulness of Carbon Nanotubes as Antiviral Compounds for Treating Alzheimer Disease
来源期刊 阿尔茨海默氏病研究进展(英文) 学科 医学
关键词 Carbon Nanotubes (CNTs) Alzheimer Disease (AD) Acetylcholine (ACh) (Aricept) Ravastigmine (RAV) (Exelon) Mitochondria (MTCDH) LYSOSOMES Van Der WAALS Interaction and LENNARD-JONES Potential
年,卷(期) 2018,(3) 所属期刊栏目
研究方向 页码范围 79-92
页数 14页 分类号 R73
字数 语种
DOI
五维指标
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研究主题发展历程
节点文献
Carbon
Nanotubes
(CNTs)
Alzheimer
Disease
(AD)
Acetylcholine
(ACh)
(Aricept)
Ravastigmine
(RAV)
(Exelon)
Mitochondria
(MTCDH)
LYSOSOMES
Van
Der
WAALS
Interaction
and
LENNARD-JONES
Potential
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
阿尔茨海默氏病研究进展(英文)
季刊
2169-2459
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
30
总下载数(次)
0
总被引数(次)
0
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