New Method for Injectable Quinine Quality Assurance Control Using a Multi-Spectral Microscope

• 作者: A. BA A. Sow I. Traore T. Diallo
• 来源期刊: 光学与光子学期刊(英文)
• 学科: 医学
• 关键词: INJECTABLE QUININE Area Under Curve MULTISPECTRAL MICROSCOPE ABSORBANCE
• 年，卷（期）: 2018,（3）
• 页码范围: 66-74
• 页数: 9页
• 分类号: R73

摘要

Africa is the world region that is most affected by malaria. Among the therapies used, injectable quinine is considered to be one of the effective antimalarial drug, however non-quality assured antimalarials clearly have a strong market penetration across Africa. To overcome this problem, it becomes more and more necessary to set up quantitative and qualitative analysis system for antimalarial quality control. The objective of the present investigation is an attempt to use customized multispectral microscope equipped with UV-Visible lasers for injectable quinine quality assurance control routinely. For that, we have established the calibration curve of quinine solution concentration as a function of area under light intensity histogram crossing the solution. From this calibration curve, we can check the conformity of any injectable quinine according to the pharmacopoeia involved. The proposed technique is a promising alternative for drug quality control routinely.