Case of human immunodeficiency virus infection presenting as a tip variant of focal segmental glomerulosclerosis:A case report and review of the literature

• 作者: Akira Shimizu Asumi Takeda Daiki Goto Hideo Yasuda Kazuhisa Ohishi Naro Ohashi Yoshihide Fujigaki
• 来源期刊: 世界肾病学杂志：英文版
• 学科: 医学
• 关键词: Focal segmental GLOMERULOSCLEROSIS TIP VARIANT ANTIRETROVIRAL THERAPY CORTICOSTEROID THERAPY Human immunodeficiency virus
• 年，卷（期）: 2018,（4）
• 页码范围: 90-95
• 页数: 6页
• 分类号: R

摘要

The incidence of the collapsing variant of focal segmental glomerulosclerosis(FSGS)as a human immunodeficiency virus(HIV)-associated nephropathy has reduced since the introduction of antiretroviral therapy(ART).However,the incidence of other variants of FSGS,except for the collapsing variant,is increasing,and its therapeutic strategies remain uncertain.A 60-year-old HIV infected man in remission with ART was admitted for progressive renal insufficiency and nephrotic-ranged proteinuria.Renal biopsy revealed a tip variant of FSGS and his clinical manifestations resolved with corticosteroid therapy.HIV infected patients might develop non-collapsing FSGS,including tip variant of FSGS and corticosteroid therapy might be effective for them.A renal biopsy might be essential to determine the renal histology and to decide on corticosteroid therapy.