Hepatitis C virus:Morphogenesis,infection and therapy

• 作者: Sylvie Lagaye Vladimir Alexei Morozov
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: HEPATITIS C VIRUS Transmission Molecular biology Pathogenesis In vitro and ex vivo models of HEPATITIS C VIRUS INFECTION Treatment
• 年，卷（期）: 2018,（2）
• 页码范围: 186-212
• 页数: 27页
• 分类号: R

摘要

Hepatitis C virus(HCV)is a major cause of liver diseases including liver cirrhosis and hepatocellular carcinoma.Approximately 3%of the world population is infected with HCV.Thus,HCV infection is considered a public healthy challenge.It is worth mentioning,that the HCV prevalence is dependent on the countries with infection rates around 20%in high endemic countries.The review summarizes recent data on HCV molecular biology,the physiopathology of infection(immune-mediated liver damage,liver fibrosis and lipid metabolism),virus diagnostic and treatment.In addition,currently available in vitro,ex vivo and animal models to study the virus life cycle,virus pathogenesis and therapy are described.Understanding of both host and viral factors may in the future lead to creation of new approaches in generation of an efficient therapeutic vaccine.