Digital liver biopsy:Bio-imaging of fatty liver for translational and clinical research

• 作者: Amalia Gastaldelli Andrea De Nicola Bruno Gridelli Claudio Tiribelli Eleni Rebelos Emanuele Neri Fabio Farinati Ferruccio Bonino Francesco Callea Francesco Faita Luca Valenti Marcello Mancini Marco Salvatore Maurizia R Brunetto Nicole Di Lascio Paul Summers Peppino Mirabelli Piero A Salvadori
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: BIOBANK BIO-IMAGING FATTY LIVER Genomics LIVER biopsy LIVER cancer Non-alcoholic FATTY LIVER disease Non-alcoholic steatohepatitis Magnetic resonance Radiomics Ultrasound
• 年，卷（期）: 2018,（2）
• 页码范围: 231-245
• 页数: 15页
• 分类号: R

摘要

The rapidly growing field of functional,molecular and structural bio-imaging is providing an extraordinary new opportunity to overcome the limits of invasive liver biopsy and introduce a“digital biopsy”for in vivo study of liver pathophysiology.To foster the application of bio-imaging in clinical and translational research,there is a need to standardize the methods of both acquisition and the storage of the bio-images of the liver.It can be hoped that the combination of digital,liquid and histologic liver biopsies will provide an innovative synergistic tri-dimensional approach to identifying new aetiologies,diagnostic and prognostic biomarkers and therapeutic targets for the optimization of personalized therapy of liver diseases and liver cancer.A group of experts of different disciplines(Special Interest Group for Personalized Hepatology of the Italian Association for the Study of the Liver,Institute for Biostructures and Bio-imaging of the National Research Council and Bio-banking and Biomolecular Resources Research Infrastructure)discussed criteria,methods and guidelines for facilitating the requisite application of data collection.This manuscript provides a multi-Author review of the issue with special focus on fatty liver.