Re-treatment Using Cetuximab and Chemotherapy in Patients with Metastatic Colorectal Cancer Harboring Wild-type RAS Gene

• 作者: Kakil Ibrahim Rasul Mohamed U Al-Homsi
• 来源期刊: 现代肿瘤学研究进展(英文)
• 学科: 医学
• 关键词: Metastatic colorectal cancer ANTI-EGFR antibodies CETUXIMAB K-RAS CHEMOTHERAPY
• 年，卷（期）: xdzlxyjjzyw_2018,（6）
• 页码范围: 18-21
• 页数: 4页
• 分类号: R73

摘要

Colorectal cancer is a heterogeneous disease.Activating mutations in genes like K-RAS,BRAF,and PI3K contribute towards a poor prognosis of the disease.In this report,we present the case of re-treatment of a 58-year old patient of metastatic colorectal cancer with a combination of anti-EGFR and chemotherapy.The patient who harbored wild-type RAS gene was administered several lines of therapies including anti-EGFR antibodies.In spite of the different regimens involved,a significant progression of disease involving metastasis to the lungs and the brain was observed.On re-treatment with cetuximab and chemotherapy,the quality of life improved and the tumor biomarkers decreased.Re-treatment with anti-EGFR antibodies and chemotherapeutic agents can be an option for patients showing adverse prognosis after several lines of therapies.