C19-Diterpenoid alkaloid arabinosides from an aqueous extract of the lateral root of Aconitum carmichaelii and their analgesic activities

• 来源期刊: 药学学报（英文版）
• 关键词: Ranunculaceae Aconitum carmichaelii C19-diterpenoid alkaloid Arabinoside Aconicarmichosides E-L Analgesic effect Structure-activity relationship
• 年，卷（期）: 2018,（3）
• 页码范围: 409-419
• 页数: 11页
• 语种: 英文
• DOI: 10.1016/j.apsb.2018.03.009

摘要

Eight new C19-diterpenoid alkaloid arabinosides, named aconicarmichosides E-L (1-8), were isolated from an aqueous extract of the lateral roots of Aconitum carmichaelii (Fu Zi). Their structures were determined by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds I-8, together with the previously reported four neoline 14-O-arabinosides from the same plant, represent the only examples of glycosidic diterpenoid alkaloids so far. At a dose of 1. 0 mg/kg (i. p. ), as compared with the black control, compounds 1, 2, and 4-6 exhibited analgesic effects with ＞65. 6％ inhibitions against acetic acid-induced writhing of mice. Structure-activity relationship was also discussed.