The Different Effect of R and S Albuterol on Proliferation and Migration of Airway Smooth Muscle Cells

• 作者: Bin Gao Ping Chen Qifeng Jiang
• 来源期刊: 生物医学工程(英文)
• 学科: 医学
• 关键词: ALBUTEROL ASTHMA SMOOTH MUSCLE Cells MIGRATION PROLIFERATION
• 年，卷（期）: 2018,（8）
• 页码范围: 207-214
• 页数: 8页
• 分类号: R73

摘要

studies have shown that the R- and S-enantiomers of racemic albuterol, a β2-adrenergic receptor agonist used in asthma treatment, have differential effects on the contractile properties of airway smooth muscle. However, the effect of albuterol on the proliferation and migration has never been tested. Since (R)-, but not (S)-albuterol enhances bronchodilation, we expect the two racemic isomers would also affect proliferation and migration of tracheal cells differentially. By monitoring migratory properties of airway smooth muscle cells in the presence of albuterol isomers, the different effect of albuterol on proliferation and migration of airway smooth muscle cells is probed. The results show Both of R- and S-albuterol could inhibit the proliferation of smooth muscle cells and the inhibition ratio of these two isomers had no significant difference;R-albuterol, but not S-albuterol, inhibited cell migration.