cGAS-STING pathway in senescence-related inflammation

• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2018,（3）
• 页码范围: 308-310
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/nsr/nwx146

摘要

Cellular senescence marked with persistent cell cycle arrest plays critical roles in orchestrating tissue remodeling and immune surveillance in response to multiple developmental and physiological stimuli.However,chronic or persistent cellular senescence can promote aberrant inflammatory responses,therefore is linked with variable pathogeneses such as fibrosis,cancer,autoimmune diseases,cardiovascular disease and neurodegenerative disease [1].Identifying how the immune system detects and responds to senescence signals is critical for our better understanding of the interplay between senescence progression and inflammation,and the pathogenesis of age-related diseases [1].