Primary hepatic peripheral T-cell lymphoma associated with Epstein-Barr viral infection

• 作者: Daryl Ramai Emmanuel Ofori Madhavi Reddy Sofia Nigar
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: PRIMARY LYMPHOMA Liver cancer Non-Hodgkin’s LYMPHOMA T-CELL LYMPHOMA
• 年，卷（期）: 2018,（2）
• 页码范围: 347-351
• 页数: 5页
• 分类号: R

摘要

Primary hepatic peripheral T-cell lymphoma(H-PTCL)is one of the rarest forms of non-Hodgkin lymphoma.We report a patient who presented with worsening jaundice,abdominal pain,and vomiting.Laboratory values were significant for elevated total bilirubin,alkaline phosphatase,and liver aminotransferases.Following a liver biopsy,histopathology revealed several large dense clusters of atypical T-lymphocytes which were CD2+,CD3+,CD5+,CD7-,CD4+,CD8-,CD56-,CD57-,CD30+by immunohistochemistry.The proliferation index was approximately 70%by labeling for ki67/mib1.The above histological profile was consistent with peripheral T-cell lymphoma of the liver.Epstein-Barr viral serology indicated a remote infection,a likely risk factor for PTCL.Bone marrow biopsy was negative for malignancy,further supporting hepatic origin.