Helioscopianoids A-Q, bioactive jatrophane diterpenoid esters from Euphorbia helioscopia

• 来源期刊: 药学学报（英文版）
• 关键词: Euphorbia helioscopia Jatrophanes Helioscopianoids A-Q P-glycoprotein (ABCB 1)inhibitory activity Neuroprotective effect
• 年，卷（期）: 2018,（5）
• 页码范围: 805-817
• 页数: 13页
• 语种: 英文

摘要

The EtOH extracts of the whole plants of Euphorbia helioscopia afforded 17 new jatrophane diterpenoid esters,helioscopianoids A-Q (1-17),along with eight known compounds (18-25).Their structures were elucidated by extensive spectroscopic methods and Mo2(OAc)4-induced ECD analysis,and the structures of compounds 1,2,and 7 were confirmed by X-ray crystallography.Compounds 1-17 were evaluated for inhibitory effects on P-glycoprotein (P-gp) in an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR) and neuroprotective effects against serum deprivationinduced and rotenone-induced PC12 cell damage.Compounds 8 and 16 increased the accumulation of ADM in MCF-7/ADR cells by approximately 3-fold at a concentration of 20 μmol/L.Compound 8 could attenuate rotenone-induced PC12 cell damage,and compounds 2,8,and 12 showed neuroprotective activities against serum deprivation-induced PC 12 cell damage.