A Novel Combined Approach for Metastatic Breast Cancer with Dural and Leptomeningeal Disease with an Impressive Clinical Outcome: A Case Study

• 作者: Christopher Duma Julie Taguchi M. A. Nezami
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: BREAST CANCER METASTATIC LEPTOMENINGEAL DISEASE DURAL DISEASE
• 年，卷（期）: azzlyw_2018,（3）
• 页码范围: 274-280
• 页数: 7页
• 分类号: R73

摘要

Concurrent dural and leptomeningeal metastatic carcinomatosis are very rare and have a poor prognosis. Here we present a woman with advanced estrogen receptor (ER) positive and progesterone receptor (PR) positive breast cancer who presented with leptomeningeal disease. Patient underwent multi targeted epigenetic therapies applied in a protocol called MTET. She continued to respond to the interval treatment, which consisted only of the nutraceutical agents. Here we discuss her case in detail and we believe that such an example might be applied to other patients in this situation resulting clinical improvement and less toxicity.