Role of lncRNAs in GI Cancer

• 作者: Anju Mullath Murali Krishna
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: lncRNA CANCER PANCREATIC GASTRIC HEPATOCELLULAR COLORECTAL
• 年，卷（期）: 2018,（3）
• 页码范围: 281-298
• 页数: 18页
• 分类号: R73

摘要

lncRNAs forms a part of the non coding part of human genome. This term denotes specific non coding RNAs with nucleotide length more than 200. They have been shown to affect various physiological and pathological processes within the human body. Of interest is their role in malignant transformation in several cancers. In this review, the role of lncRNAs in GI cancers namely pancreatic cancer, gastric cancer, hepatocellular cancer and colorectal cancer have been explained in brief. These lncRNAs have shown to be useful as a marker for detection and prognosis of various malignancies. They also have shown to have therapeutic potential. Various relevant lncRNAs in each section has also been mentioned.