The present research attempted a Large-Eddy Simulation (LES) of airflow over a steep, three-dimensional isolated hill by using the latest multi-cores multi-CPUs systems. As a result, it was found that 1) turbulence simulations using approximately 50 million grid points are feasible and 2) the use of this system resulted in the achievement of a high computation speed, which exceeded the speed of parallel computation attained by a single CPU on one of the latest supercomputers. Furthermore, LES was conducted by using the multi-GPUs systems. The results of these simulations revealed the following findings: 1) the multi-GPUs environment which used the NVDIA? Tesla M2090 or the M2075 could simulate turbulence in a model with as many as approximately 50 million grid points. 2) The computation speed achieved by the multi-GPUs environments exceeded that by parallel computation which used four to six CPUs of one of the latest supercomputers.