A Numerical Study of Passive Receptor-Mediated Endocytosis of Nanoparticles:The Effect of Mechanical Properties

• 作者: Huaxiong Huang Xiaobo Gong Xinyue Liu Yunqiao Liu
• 来源期刊: 工程与科学中的计算机建模(英文)
• 学科: 工学
• 关键词: RECEPTOR-MEDIATED ENDOCYTOSIS NANOPARTICLE UPTAKE optimization method receptor-ligand BONDS drug delivery
• 年，卷（期）: 2018,（8）
• 页码范围: 281-300
• 页数: 20页
• 分类号: TB3

摘要

In this work,a three-dimensional axisymmetric model with nanoparticle,receptor-ligand bonds and cell membrane as a system was used to study the quasi-static receptor-mediated endocytosis process of spherical nanoparticles in drug delivery.The minimization of the system energy function was carried out numerically,and the deformations of nanoparticle,receptor-ligand bonds and cell membrane were predicted.Results show that passive endocytosis may fail due to the rupture of receptor-ligand bonds during the wrapping process,and the size and rigidity of nanoparticles affect the total deformation energy and the terminal wrapping stage.Our results suggest that,in addition to the energy requirement,the success of passive endocytosis also depends on the maximum strength of the receptor-ligand bonds.