Ratio of mean platelet volume to platelet count is a potential surrogate marker predicting liver cirrhosis

• 作者: Hiroya Iida Kosuke Matsui Masaki Kaibori Masanori Kon Morihiko Ishizaki
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Mean PLATELET volume PLATELET COUNT LIVER cirrhosis Hepatic functional RESERVE LIVER FIBROSIS
• 年，卷（期）: sjgbxzzywbdzb_2018,（1）
• 页码范围: 82-87
• 页数: 6页
• 分类号: R

摘要

AIM To provide a simple surrogate marker predictive of liver cirrhosis(LC).METHODS Specimens from 302 patients who underwent resection for hepatocellular carcinoma between January 2006 and December 2012 were retrospectively analyzed.Based on pathologic findings,patients were divided into groups based on whether or not they had LC.Parameters associated with hepatic functional reserve were compared in these two groups using Mann-Whitney U-test for univariate analysis.Factors differing significantly in univariate analyses were entered into multivariate logistic regression analysis.RESULTS There were significant differences between the LC group(n=100)and non-LC group(n=202)in prothrombin activity,concentrations of alanine aminotransferase,aspartate aminotransferase,total bilirubin,albumin,cholinesterase,typeⅣcollagen,hyaluronic acid,indocyanine green retention rate at 15 min,maximal removal rate of technitium-99m diethylene triamine pentaacetic acid-galactosyl human serum albumin and ratio of mean platelet volume to platelet count(MPV/PLT).Multivariate analysis showed that prothrombin activity,concentrations of alanine aminotransferase,aspartate aminotransferase,total bilirubin and hyaluronic acid,and MPV/PLT ratio were factors independently predictive of LC.The area under the curve value for MPV/PLT was 0.78,with a 0.8 cutoff value having a sensitivity of 65%and a specificity of 78%.CONCLUSION The MPV/PLT ratio,which can be determined simply from the complete blood count,may be a simple surrogate marker predicting LC.