DNA nanomachines: monitoring molecular encounter dynamics in live cell membranes

• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2018,（3）
• 页码范围: 300-301
• 页数: 2页
• 语种: 英文
• DOI: 10.1093/nsr/nwx091

摘要

The cell membrane features a variety of heterogeneous and dynamic compartments to regulate cell structure and function.These compartments are generally classified into a relatively packed,lipidordered (Lo) domain (10-200 nm) enriched in saturated lipids and cholesterol,and a more fluid,liquid-disordered (Ld)domain comprising mainly unsaturated lipids [1].According to the lipid raft theory,Lo domains,which selectively recruit specific lipids and proteins,serve as critical platforms for signal transduction and membrane protein trafficking [2].There-fore,resolving the interplay and dynamics of lipids and proteins on the plasma membrane is of great importance to unveil the properties and biological relevance of membrane domains.