Efficacy of intra-arterial contrast-enhanced ultrasonography during transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma

• 作者: Iruru Maetani Kazue Shiozawa Manabu Watanabe Shuhei Yamamoto Takashi Ikehara Takashi Matsui Yoshinori Igarashi Yoshinori Saigusa
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Hepatocellular carcinoma CONTRAST-ENHANCED ULTRASONOGRAPHY DRUG-ELUTING BEADS Transarterial CHEMOEMBOLIZATION INTRA-ARTERIAL CONTRAST-ENHANCED ULTRASONOGRAPHY
• 年，卷（期）: 2018,（1）
• 页码范围: 95-104
• 页数: 10页
• 分类号: R

摘要

AIM To assess the usefulness of intra-arterial contrastenhanced ultrasonography(IAUS)during transarterial chemoembolization(TACE)with drug-eluting beads(DEB)for hepatocellular carcinoma(HCC).METHODS Thirty two patients with 39 HCC underwent DEB-TACE guided with IAUS,and examined by contrast-enhanced ultrasonography(CEUS)or dynamic CT after DEB-TACE were enrolled in this study.CEUS findings before DEBTACE and IAUS findings were compared.Treatments judged to be complete and incomplete for lesions were appropriate and insufficient,respectively.Findings on CEUS and/or dynamic CT performed 1,3 and 6 mo after DEB-TACE were evaluated using mRECIST(CR/PR/SD/PD).RESULTS The treatments were complete and incomplete in 26 and 13 lesions,respectively.On imaging evaluation using CEUS and/or dynamic CT one month after treatment,25 and 1 lesions were judged to be CR and PR,respectively,and at 6 mo after treatment,the results were CR,PR,SD and PD for 24,1,0 and 1 of these lesions,respectively,in the 26 completely treated lesions.Of the 13 lesions in which treatment was incomplete,the results on imaging at one month after treatment were CR,PR,SD and PD for 0,6,4 and 3 lesions,respectively.The overall CR rate at 6 mo after treatment was 61.5%(24/39).CONCLUSION A combination of DEB-TACE with IAUS can improve the therapeutic effects in patients with HCC.