The Expression of E-Cadherin and Vimentin in Non-Small-Cell Lung Cancer and Their Correlation with Epithelial-Mesenchymal Transition (EMT)

• 作者: Mingyuan Tian Yu Li
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: LUNG CANCER E-CADHERIN VIMENTIN EMT
• 年，卷（期）: 2018,（5）
• 页码范围: 1-8
• 页数: 8页
• 分类号: R73

摘要

To investigate the expression of E-cadherin and Vimentin protein in non-small-cell lung cancer (NSCLC) and to analyze the relationship between their expression and epithelial-mesenchymal transition (EMT). Immuno-chemical staining with SP method was conducted to detect the protein expression of E-cadherin and Vimentin in 44 lung cancer tissues. E-cadherin was highly expressed in all normal lung tissues, and Vimentin was lowly expressed in all normal lung tissues. The expression rate of E-cadherin and Vimentin was 40.9% and 25.0% in NSCLC cases. The expressions of E-cadherin and Vimentin were not associated with gender, age, histopathological grading, lymphatic metastasis or smoking status (P > 0.05). But they were associated with clinical stage (P < 0.05). In addition, a negative correlation between the E–cadherin and Vimentin was observed (Spearman’s r = ?0.397, p < 0.05). E-cadherin and Vimentin are involved in the transformation of epithelial cells into the mesenchymal cells, which play important role in the metastasis of lung cancer.