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摘要:
Background: To evaluate local control, survival, radiation side effects and treatment outcome in locally advanced cervical cancer patients. Materials and Methods: Among 2006-2011, 178 patients with locally advanced cervical cancer were treated with chemoradiotherapy +/-?radiotherapy and high dose rate (HDR) brachytherapy. Follow-up was complete for all patients. Concomitant chemotherapy was not administered in 44 patients due to renal impairments and ECOG of 2 - 3. Results: The median follow-up period was 34.5 months (range, 5 to 93) and 42 months (range, 14 to 93 months) for alive patients. Five years local-regional control, progression-free survival and overall survival rates were 87.8%, 58.9% and 67.3% in all patients, respectively. In this retrospective study young age, tumor diameter, stage, presence of residual tumor and administration of chemotherapy were effected in survival analysis. The parameters which affected the complete response of patients were defined as presence of concomitant chemotherapy and number of courses <5. Central region recurrence rate was defined higher in the group with treatment duration of 9 weeks and higher (p = 0.044). Conclusion: Primary chemoradiotherapy +/-?radiotherapy achieved a satisfactory rate of local control and survival rates with acceptable complications in locally advanced cervical cancer. Concomitant chemotherapy and treatment duration were the important prognostic factors for completed response locally advanced cervical cancers.
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篇名 Prognostic Factors and Treatment Outcome in 178 Locally Advanced Cervical Cancer Patients
来源期刊 妇产科期刊(英文) 学科 医学
关键词 LOCALLY ADVANCED CERVIX CANCER CHEMO-RADIOTHERAPY CERVIX CANCER
年,卷(期) 2018,(5) 所属期刊栏目
研究方向 页码范围 485-496
页数 12页 分类号 R73
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LOCALLY
ADVANCED
CERVIX
CANCER
CHEMO-RADIOTHERAPY
CERVIX
CANCER
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研究分支
研究去脉
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相关学者/机构
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妇产科期刊(英文)
月刊
2160-8792
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
642
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0
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0
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