Chronic rhinosinusitis (CRS) is a Common disease of otorhinolaryngology head and neck surgery,manifested as nasal-sinus mucosal chronic inflammation.However,the pathogenesis of CRS is not clear.There are studies found that mieroRNA (miRNA) involved in CRS gene regulation.In this review,we summarizes the expression of miRNAs in CRS,with the in-depth study of the role of miRNAs in CRS,and will further elucidates the pathogenesis of CRS.