Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2018,（5）
• 页码范围: 601-604
• 页数: 4页
• 语种: 英文
• DOI: 10.1038/s41422-018-0019-5

摘要

Dear Editor, Neuroendocrine tumors (NETs) comprise a heterogeneous spectrum of neoplasms originating from neuroendocrine cells in various organs — most commonly in the endocrine glands and the gastrointestinal tract.1 The molecular and etiological features of NETs arising from different organs are still far from clarified. Therefore, systematic analysis of genomic alternations and their contribution to core pathways in NETs is urgently needed for the development of novel diagnostic, therapeutic strategies and personalized management of patients. Here, we investigated somatic mutations across 21 NET types through pan-cancer analysis and identified 86 candidate driver genes. Further analysis of druggability and panel sequencing of these genes provide potential diagnostic and therapeutic targets for NETs.