Exosomes as Drug Carriers for Clinical Application

• 作者: Di Cuixia Li Hongyan Zhang Hong
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报:英文版
• 学科: 医学
• 关键词: EXOSOMES DIAGNOSIS METASTASIS
• 年，卷（期）: 2018,（1）
• 页码范围: 155-157
• 页数: 3页
• 分类号: R73

摘要

Exosomes denote a family of nano-sized membrane extracellular vesicles with a diameter in the range of 40∼130 nm that are secreted by most cell types of the body[1].Initial studies suggest that this extracellular vesicle is a metabolic waste that cells secrete.However,more and more studies have shown that exosomes act as mediators of cell-to-cell signaling and participate in a variety of physiological and pathological activities in organisms[2].Due to such characteristics,analyzing the specific biomarkers[3]carried therein is expected to be a non-invasive method for diagnosis and monitoring of tumors.Additionally,exosomes are not only important for tumor immunity,tumor invasion,metastasis and tumor resistance,but also has important value in the diagnosis and treatment of tumor.Exosomes can exert important effects in various disease models[4].Overall studies give an idea that exosomes play both cancer-promoting and malignant functions in malignant tumors[5].