Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2018,（6）
• 页码范围: 693-695
• 页数: 3页
• 语种: 英文

摘要

Dear Editor, Non-small cell lung cancer (NSCLC) accounts for over 75％ cases of lung cancer,the leading cause of cancer deaths in the world.Most NSCLC patients are diagnosed at an advanced stage due to the inadequate screening program and late onset of clinical symptoms,leading to poor prognosis.1 Discovery of accurate and sensitive biomarkers is in urgent need.Recently,circular RNAs (circRNAs) are emerging as a novel biomarker because of their conservation,abundance,cell type-specific and tissue-specific expression,and their roles in disease progression.2,3