Protective Effect of MitoQ Against 56Fe Radiation Induced Brain Mitochondria DNA Damage in Mice

• 作者: Gan Lu Zhang Hong
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报:英文版
• 学科: 经济
• 关键词: ORGANS attracting SHAPED
• 年，卷（期）: 2018,（1）
• 页码范围: 164-165
• 页数: 2页
• 分类号: F42

摘要

With deep-space exploration missions being extended,the impact of the space environment on the health of astronauts is attracting more and more concern.During space flight,exposure to relatively high doses and various forms of radiation.Iron ion(56Fe)is main radiation sources in deep space and has received much attention[1].Exposure to 56Fe radiation during space missions poses a significant risk to the central nervous system and radiation exposure significantly affects the hippocampus.Radiation exposure is intimately linked to the production of reactive oxygen species(ROS)and due to its high oxygen consumption and metabolic rate,the brain is more susceptible to ROS and oxidative stress than other organs.Previous studies have shown that 56Fe irradiation induced cognitive deficit in mice as a result of oxidative stress[2].In the brain,the major source of ROS-induced the oxidative stress is due to the mitochondria[3].Mitochondria are rod-shaped organelles and can be considered the power generators of the cell,converting oxygen and nutrients into adenosine triphosphate(ATP).Mitochondria are directly associated with numerous physiological and pathological functions,including oxidative phosphorylation,calcium homeostasis,reactive oxygen management,and programmed cell death[4].The brain contains a large number of mitochondria and the phosphorylation systems are to more active in the brain than in other organs.The aim of the current study was to evaluate the mitochondrial respiration injury induced by 56Fe irradiation in the mouse brain and investigate effect of MitoQ on the injury.