A smart cluster paradigm based Mo-containing polyoxometalate as a new therapeutic strategy for tumor-specific photothermal therapy

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2018,（14）
• 页码范围: 877-878
• 页数: 2页
• 语种: 英文

摘要

A desirable near-infrared (NIR) photothermal agent based on Mo-based polyoxometalate cluster with self-adaptive electronic structure for tumor acidity/reducibility-specific therapy was reported in a paper on Journal of the American Chemical Society [1]. This "small-big" cluster paradigm displayed the capacity of self-assemble to big molecules under activation both the acidity and reducibility in the tumor microenvironment for enhanced phototherapy therapeutic efficiency while still keeping small molecule- like before embedded in cancerous regions to prevent possible side effects on normal tissue.