组织再生材料:从基础研究创新到临床转化应用

• 作者: 付小兵 姜玉峰 胡添
• 来源期刊: 科学通报
• 年，卷（期）: 2018,（21）
• 所属期刊栏目: 观点/材料科学
• 页码范围: 2111-2115
• 页数: 5页
• 语种: 中文
• DOI: 10.1360/N972018-00461

摘要

Biomaterials are the focus of material science and life science, as tissue repair and regenerative medicine research have been regarded as the resolution of the increasing need in national health care. Biomaterials have been developed into bio-degradable and bioactive third-generation materials after the first generation of inert materials and the second generation of active or degradable materials. In recent years, with biomaterials been developing into artificial extracellular matrix, the usage of biomaterials to build cell tissue microenvironment plays an important regulatory role in promoting cell adhesion, morphology, proliferation and differentiation, and tissue structure and function of repair and reconstruction of organs. At present, with the advance of surface modification and genetic engineering technology at home and abroad, synthesis of fusion protein biomaterials with compound functions, cell specificity of polysaccharide and dynamic way of the combination of intelligent hydrogels, such as bionic cells and bionic extracellular microenvironment, provide a new design method and technology. In addition, through three-dimensional (3 D) structure which could simulate cell microenvironment in order to promote cell growth, it can not only provide enough space for cells, but also favor the growth of cell adhesion, matrix deposition, oxygen and nutrients, and conducive to blood vessels and nerves. Because of the complexity of the human body, using cultured cells and bioactive materials to replace or regenerate tissues and organs involves interactions between cells and materials. Besides, partial repair and regeneration of single tissue components have been achieved in numerous organs. However, complex tissue structures need synchronous repair and regeneration which just as the situation happens in lower animal those have full potential to regeneration limb or large part of their body. The realization of synchronous repair and regeneration requires the suitable injury and repair surrounding environment to initiate the repair and regeneration process. It also needs the right cellular candidates with tightly regulation to drive and lead the whole process of repair and regeneration. In addition, the timing of repair and regeneration also should be precisely control, such as how long the repair needs and when the regeneration process stops. In summary, to achieve perfect repair and regeneration needs the right cell types to drive the process in suitable environment at the right moment. With the material implanted in body, it would involve in immune system, development, blood supply, innervation, function adjustment, and aging, which need the corporation of multidisciplinary researchers in cell biology, developmental biology, molecular biology, biology, materials science, and clinical medicine. The Xiangshan Science Conference on biomaterials and tissue regeneration has further clarified the research content and key points in this field, which is worthy of attention.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	付小兵		215	1520	18.0	26.0
2	姜玉峰		3	76	2.0	3.0
3	胡添		1	0	0.0	0.0