Discovery of multi-drug resistant, MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China
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摘要:
An endemic multi-drug resistant ST117 E.coli isolate coproducing MCR-1 and 3 ESBL loci was,for the first time,detected from diseased chicken,Liaoning Province,in Northeast China,from 2011 to 2012.Wholegenome sequencing revealed 5 unique plasmids,namely pHXH-1,pHXH-2,pHXH-3,pHXH-4 and pHXH-5).Among them,pHXH1 and pHXH4 encode ESBL,and pHXH-5 mediates MCR-1 colistin resistance.The results indicate that the potentially-national dissemination of MCR-1-positive pathogens with pan-drug resistance proceeds via food chains.