MicroRNA作为甲状腺乳头状癌生物标记物的研究进展

• 作者: 余杰情 周文胜 张思林 胡仿玲
• 来源期刊: 临床耳鼻咽喉头颈外科杂志
• 学科: 医学
• 关键词: 甲状腺乳头状癌 microRNA 生物标记物 诊断 复发 预后
• 年，卷（期）: 2018,（15）
• 所属期刊栏目: 综述
• 页码范围: 1199-1202
• 页数: 4页
• 分类号: R736.1
• 语种: 中文
• DOI: 10.13201/j.issn.1001-1781.2018.15.019

摘要

Thyroid cancer is a common malignancy derived from the endocrine system and the incidence of thyroid cancer is on the rise.Papillary thyroid carcinoma (PTC) is the most common type, and 90％ of PTC patients have long-term survival, but the recurrence rate is still as high as 30％.Current diagnostic and postoperative monitoring techniques have been developed, but their negative rates and interfering factors also occupy an absolute proportion, and lack specific markers for the prognosis of PTC.Studies have shown that microRNAs (miRNAs) are associated with the development, metastasis and invasiveness of PTC and as a biomarker to aid in the diagnosis and monitoring of recurrence, and to determine the prognosis for specific markers.The future of PTC diagnosis, treatment and improve prognosis has broad prospects.This review mainly describes the development of miRNA as biomarkers for the diagnosis, recurrence and prognosis of PTC.