Effect of elasticity mismatch on cell deformation and migration:A phase-field study

• 来源期刊: 中国物理B（英文版）
• 关键词: cell migration elastic mismatch phase-field simulations
• 年，卷（期）: 2018,（11）
• 页码范围: 294-299
• 页数: 6页
• 语种: 英文
• DOI: 10.1088/1674-1056/27/11/116201

摘要

The phase-field model for cell migration is used to study the effect of elasticity mismatch on the migration dynamics of multiple cells in a confluent monolayer,where one tagged cell is embedded by a number of normal cells and both types of cells are supposed to have the same properties except elasticity.Our results show that a larger elasticity mismatch leads to a larger difference in shape change between the tagged cell and the normal cells.We find that the bursts of velocity always fall behind the peak of the perimeter,and the shape change of the tagged cell results in the accelerated motion of the tagged cell in the whole process.Moreover,the variation of the averaging cell perimeter ratio (L)tag/(L)normal with the increase of the elasticity ratio γtag/γnormal for different active velocities |va| is analyzed.We find that (L)tag/(L)normal decreases with the increase of γtag/γormal,following a simple power law function.Our results highlight the important role played by the cell elasticity mismatch in cell deformation and migration.