Hyperhidrosis of Central Hypogonadism Leading to Diagnosis of Shapiro Syndrome: Temperature Dysregulation, Hypothermia and Agenesis of the Corpus Callosum

• 作者: Dana Danley Emily A. Beckett Megan A. Traxinger Udaya M. Kabadi
• 来源期刊: 内分泌与新陈代谢疾病期刊(英文)
• 学科: 医学
• 关键词: HYPERHIDROSIS CENTRAL HYPOGONADISM TEMPERATURE DYSREGULATION Callosal Agenesis Shapiro SYNDROME
• 年，卷（期）: 2019,（1）
• 页码范围: 1-7
• 页数: 7页
• 分类号: R73

摘要

Background: Central or hypothalamic hypogonadism as an initial manifestation of Shapiro Syndrome has not been described in the literature. Herein, we report first case in which initial presentation of central hypogonadism led to a confirmed diagnosis of Shapiro Syndrome during a casual evaluation of hypothalamic pituitary anatomy with MRI of brain. Case presentation: 53 year old Caucasian man was documented to manifest Central or hypogonadotropic hypogonadism following evaluation of excessive sweating episodes, lack of libido and erectile dysfunction for a duration of several years. Brain MRI performed for assessment of the etiology documented no pituitary abnormality. Instead agenesis of Corpus Callosum was noted. The subject had been hospitalized on many occasions at this and several other medical centers with hypothermia or hyperthermia without a documentation of a definite cause. Therefore, the diagnosis of Shapiro Syndrome was made. Conclusion: This report is the first documentation of subject manifesting central, more likely to be hypothalamic rather than hypogonadotropic hypogonadism in conjunction with Shapiro Syndrome.