Inflammation and cardiovascular disease

• 作者: Christina G Katsiari Dimitrios P Bogdanos Lazaros I Sakkas
• 来源期刊: 世界转化医学杂志
• 学科: 医学
• 关键词: Cardiovascular DISEASE Coronary artery DISEASE ATHEROSCLEROSIS INFLAMMATION INNATE IMMUNITY Adaptive IMMUNITY BIOLOGIC drugs
• 年，卷（期）: sjzhyxzz_2019,（1）
• 页码范围: 1-8
• 页数: 8页
• 分类号: R

摘要

Cardiovascular disease(CVD)has been associated with the so-called traditional risk factors,such as hypertension,hypercholesterolemia and cigarette smoking.Chronic inflammation,exemplified by elevated high sensitivity C-reactive protein,has been added to these risk factors for CVD as non-traditional risk factor.There are two aspects in this association.The first is whether inflammation plays a pathogenic role in traditional risk factors-mediated CVD or it is just an epiphenomenon.The second is whether chronic inflammation caused by an inflammatory disease has any impact on CVD.Accumulated data have shown that inflammation has a central and inciting role in the development of atherosclerosis leading to increased CVD risk.How inflammation contributes to CVD is a topic of continuous research where mechanisms involving both innate and adaptive immune pathways are involved.Endothelial dysfunction,oxidative stress in vascular endothelial cells,macrophage accumulation,formation of inflammasome,production of tumor necrosis factor(TNF)-a,IL-1 and IL-6 characterize the inflammatory process leading to atherogenesis.Recently clonal hematopoiesis of indeterminate potential represents a surprising and novel mechanism underlying atherogenesis.Data from chronic rheumatic inflammatory diseases exemplify the complexity of mechanisms leading to increased CVD,while they also provide evidence that anti-inflammatory biologic drugs,such as anti-TNF and anti-IL6 agents,could control atherogenesis and ameliorate CVD risk.Recent groundbreaking work using biologic anti-IL-1b therapy to treat men and women who have had a prior heart attack provides the best proof of the pathogenic contribution of inflammation in the development of CVD.