DSA-Based Quantitative Assessment of Cerebral Hypoperfusion in Patients with Asymmetric Carotid Stenosis

• 作者: Gelin Xu Jie Gao Xinke Yao Xu Zhang Yan Cai Zhengze Dai Zhiyong Li
• 来源期刊: 分子与细胞生物力学(英文)
• 学科: 医学
• 关键词: CEREBRAL HYPOPERFUSION CAROTID STENOSIS quantitative functional assessment DSA
• 年，卷（期）: 2019,（1）
• 页码范围: 27-39
• 页数: 13页
• 分类号: R74

摘要

Digital subtraction angiography(DSA)is often used to evaluate the morphological and pathological changes of cerebral arteries in clinical practice.This study aims to explore the possibility of assessing cerebral hypoperfusion with DSA in patients with carotid stenosis.Thirty patients with a mild to severe stenosis on one side,and a mild stenosis on the other side of the carotid artery were recruited.Frontal,parietal,temporal and occipital lobes were chosen as regions of interest for measuring the quantitative perfusion parameters from their time-density curves(TDCs)of DSA images.The perfusion parameters were compared between the two hemispheres by using paired ttest.In addition,the bilateral asymmetry of these parameters was calculated and its correlation with the bilateral asymmetry in stenosis was analyzed.The parameters included mean transit time(MTT),time of contrast uptake(TU),time taken to the half peak value(1/2TMAX),area under the curve(AUC)were significantly prolonged at the severe stenosis side than those at the mild stenosis side in frontal lobe(P=0.013;P=0.041;P=0.009;P=0.027)and parietal lobe(P=0.008;P=0.041;P=0.002;P=0.012).The asymmetric ratios of MTT and AUC showed statistically significant correlations with stenosis asymmetry in all four lobes.MTT,TU,1/2TMAX and AUC could reflect the bilateral asymmetry of the cerebral perfusion.These DSA parameters,therefore,may be used for the evaluation of cerebral hypoperfusion caused by carotid stenosis.