Delivery of siRNA/miRNA by nanocarriers to treat colon cancer

• 作者: Xiao-Dong Wang
• 来源期刊: 精准医学研究
• 学科: 医学
• 关键词: COLORECTAL cancer MIRNA MARKERS NANOCARRIERS Gene therapy
• 年，卷（期）: 2019,（2）
• 页码范围: 52-60
• 页数: 9页
• 分类号: R

摘要

Despite the current advances in the discovery of the colorectal cancer biomarkers and in the diagnosis and treatment of CRC, the incidence and mortality of colon cancer are still increasing year by year. At present, many patients with colon cancer have been diagnosed in an advanced stage, which always accompanied by liver metastasis and distant metastasis. However, current treatments for advanced colon cancer are limited. Therefore, the delivery of siRNA/miRNA to colon cancer lesions may be a new approach to the treatment of colon cancer. This review provides ideas for the molecular treatment of colon cancer by discussing the biological characteristics of colon cancer and the regulation of important miRNA molecules in colon cancer. Moreover, this review describes the development of nanocarriers in recent years and the important role of nanocarrier materials in the targeted delivery of small molecules. On the one hand, nanocarriers can serve as small carriers or siRNA/miRNAs, and on the other hand, can transport small molecules or siRNA/miRNAs into colon cancer cells, thereby regulating key genes expression affecting colon cancer cell proliferation, metastasis, and apoptosis. Delivery of siRNA/miRNA via nanocarriers may be a novel approach to the treatment of colon cancer.