The polygenic risk in schizophrenia: assessing GWASs and evaluating Clozapine, ECT and other treatment modalities

• 作者: Shiruli Dash
• 来源期刊: TMR生命研究
• 学科: 生物学
• 关键词: SCHIZOPHRENIA traditional Chinese medicine SCHIZOPHRENIA GENETIC SCHIZOPHRENIA treatment
• 年，卷（期）: 2019,（1）
• 页码范围: 22-30
• 页数: 9页
• 分类号: Q

摘要

Research shows that the mortality rate among people with schizophrenia is up to four times higher than that in the general population. The subsequent high comorbidities and societal cost of schizophrenia necessitate finding better,more effective treatments and strategies for prevention. One of the current obstacles are the complicated gene etiologies that are involved in the pathophyslology of schizophrenia. So far, an increasing number of clinical and experimental studies show links between schizophrenia treatment and genetic conditions. Here, we analyze the literature on schizophrenia genetics, with a particular focus on the brain, the mind and environmental insults. An overlap of schlzophrenla with other psychotic disorders has also been taken into accunt with an attempt to find a parallel relationship between genetics and treatment. Finally, we summarize all the present-day treatment options for schizophrenia like clozapine and electroconvulslve therapy and also take into consideration the relatively unexplored role of traditional Chinese medicine.