Relationship between tumor lymphangiogenesis and tumor metastasis

• 作者: Rui Cao Xiong-Zhi Wu Ya-Nan Man
• 来源期刊: 肿瘤微环境研究
• 学科: 医学
• 关键词: LYMPHANGIOGENESIS TUMOR METASTASIS BIOMARKER MOLECULAR mechanism
• 年，卷（期）: 2019,（1）
• 页码范围: 14-22
• 页数: 9页
• 分类号: R73

摘要

Objective:To summarize the research progress on the relationship between tumor lymphangiogenesis and tumor metastasis.Methods:PubMed and China National Knowledge Infrastructure(CNKI)database were used to search for related literatures with the keywords of"tumor,lymphangiogenesis and lymphatic metastasis".Inclusion criteria:(1)the morphology and function of tumor lymphatic vessels;(2)the markers of lymphatic vessels;(3)the mechanism of tumor lymphangiogenesis;(4)the molecular regulation mechanism of tumor lymphangiogenesis.Results:The lymphatic vessel wall is only composed of endothelial cells,and the basement membrane is discontinuous with high permeability.The markers of lymphatic vessels include VEGFR-3,LYVE-1,podoplanin and thehomeoboxgene Prox-1,which facilitate the research on the function of lymphatic vessels in tumor.The mechanism of tumor lymphangiogenesis is very complicated,and there is no conclusion yet.It is believed that the tumor lymphangiogenesis is mainly derived from the existing lymphatic endothelial cells in the tissue.During the process of tumor lymphangiogenesis,many factors,such as VEGF-C,VEGF-D,VEGF-A,bFGF,PDGF-BB,Ang-2,NO and COX-2,are directly or indirectly involved.However,most studies believe that VEGF-C and VEGF-D are the most important regulators of tumor lymphangiogenesis.Conclusion:Tumor lymphangiogenesis is closely related to tumor lymphatic metastasis.Inhibition of tumor lymphangiogenesis can open a new way for tumor treatment.