Preoperative Short-Course Radiation Therapy in Rectal Cancer

• 作者: Huynh Thanh Hai Le Trong Hung Nguyen Thanh Ai Pham Nguyen Cuong Pham Nguyen Tuong
• 来源期刊: 美中医学:英文版
• 学科: 医学
• 关键词: Rectal cancer short-course RADIATION THERAPY PREOPERATIVE DOWNSTAGING pelvic 3D-conformal RADIATION therapy.
• 年，卷（期）: 2019,（2）
• 页码范围: 100-104
• 页数: 5页
• 分类号: R

摘要

Purpose:To evaluate the benefits of preoperative short-course radiotherapy in locally advanced rectal cancer.Patients and methods:A prospective study of 30 rectal cancer patients at T3-4M0 stage and ECOG 0-2 performed preoperative short-course radiation therapy at Hue Central Hospital Vietnam between June 2016 and July 2018,using pelvic 3D-Conformal Radiation Therapy with the total radiation dose being 25 Gy in 5 fractions over five days.Results:Mean age 57.1±13.6 with 46.7%of patients in the range of 41-60 year-old.Male/female ratio:2/1.Tumour stage T3 and T4 was 70%and 30%,respectively;stage III and stage IV was 86.7%and 13.3%,respectively.Positive lymph node rates on endoscopic ultrasound were 85.7%in T3 and 77.8%in T4.Downstaging rate for stage III,T4 and T3 was 65.4%,65.4%and 4.8%,respectively.For upper third of the rectum:100%of T3 stage patients got no downstaging.For middle rectum:downstaging rate for stage III,T4 and T3 was 55.6%,57.1%and 7.1%,respectively.For lower rectum:downstaging rate for stage III,T4 was 50.0%and 100.0%,respectively.No acute toxicity was seen,86.7%of the patients performed laparoscopic sphincter-preserving surgery.Conclusion:For the treatment of locally advanced rectal cancer,neoadjuvant therapy is standard.Preoperative short-course radiation therapy is a reasonable therapeutic option because it demonstrates benefits in tumour downstaging especially for middle and lower rectum.