The genomic and microenvironmental factors affecting neuroendocrine differentiation in prostate cancer induced by androgen deprivation therapy

• 作者: Ya-Nan Man Yan-Fang Chen
• 来源期刊: 精准医学研究
• 学科: 医学
• 关键词: Advanced PROSTATE cancer ANDROGEN DEPRIVATION therapy NEUROENDOCRINE differentiation
• 年，卷（期）: 2019,（1）
• 页码范围: 9-16
• 页数: 8页
• 分类号: R

摘要

Although advanced prostate cancer(PCa)can be initially controlled by androgen deprivation therapy(ADT),recurrence normally occurs due to the appearance of castration-resistant prostate cancer(CRPC).Neuroendocrine differentiation(NED)in PCa can be partly explained the androgen resistance and progression to CRPC.NED normally associates with more aggressive clinical behaviour and poor outcomes in PCa.Although more and more studies are performed on NED in PCa recent decades,the molecular profiles that are implicated in NED are still poorly elucidated.Of these studies,signaling factors involved in genomic and microenvironmental components are deeply researched and most likely to provide the potential therapeutic targets for advanced PCa with NED.In this article,we review the hypothesis about the origin of NE cells and the molecular mechanisms driving NED from the point of genomic and environmental views.In addition,we discuss the current potential therapeutic targets and ongoing clinical trails associated with these molecular factors for the treatment of NED patients induced by ADT.