Synthesis of Novel 4-Thiazolidinone and Bis-Thiazalidin-4-One Derivatives Derived from 4-Amino-Antipyrine and Evaluated as Inhibition of Purine Metabolism Enzymes by Bacteria

• 作者: Abdulrahman S. Alharbi Nawaa A. Alshammari Reda M. Abdel Rahman
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Synthesis 4-Thiazolidinones ANTIPYRINE INHIBITION of Purine Metabolism ENZYMES BACTERIA
• 年，卷（期）: 2019,（2）
• 页码范围: 85-95
• 页数: 11页
• 分类号: O6

摘要

Novel 4-thiazolidione and 1,4-bis-thiazolidinone derivatives bearing antipyrine moiety have been obtained from condensation of 4-aminoantipyrine 1 with aromatic/heteroaldehydes followed by cycloaddition with mercaptoacetic acid in nonpolar solvents. Structure of the products has been deduced upon their elemental analysis and spectral measurements. Most of the targets evaluated as enzymatic effect towards some bacteria (E. coli) in compare with Xanthine oxidase (from buttermilk) where the role of compounds is an inhibition of purine metabolism enzymes caused by E. coli.