Research on Drug Loading Performance of Hydroxiapatite-Gelatin Composites by Co-precipication Method

• 作者: E.Kahraman G.Nasun Saygili N.Erdol Aydin
• 来源期刊: 药剂与药理学:英文版
• 学科: 医学
• 关键词: HYDROXYAPATITE GELATIN DRUG loading composite
• 年，卷（期）: 2019,（4）
• 页码范围: 212-217
• 页数: 6页
• 分类号: R

摘要

Hydroxyapatite/polymer composites are promising materials for drug delivery applications.Studies focusing on the development of such composites are available in recent years,as using these materials as a carrier allows us to overcome the side effects of toxic drugs used especially in cancer treatments and increase treatment efficiency.In this study,hydroxyapatite-gelatin(HAp-GEL)composites are produced in the presence of simulated body fluid(SBF)as a carrier for 5-Fluorouracil(5-FU).Composites are produced by wet precipitation method at pH 7.4 and 37°C and crosslinked with glutaraldehyde(GA).In order to observe the effect of GA amount on drug loading efficiency,composites cross-linked with different amounts of GA are released in deinozed water,HCl and phosphate bufffer solution(PBS).Composites are analyzed by X-Ray Diffraction(XRD),Thermogravimetric Analyses(TGA),Scanning Electron Microscopy(SEM)and particle size distribution to observe morphology and structure.It is concluded that drug loaded HAp-GEL composites have a potential to be used in drug delivery applications.